Why most published research findings are false

A paper titled "Why Most Published Research Findings Are False" (2005) which discusses medical research, although many of the points ring true for many fields, cheers seed. Reminds me of this old chestnut "Is the scientific paper a fraud?" (1963) by Medawar.
Also, a ppt presentation on Goldberg (and other's) billion bit optimization, titled "Billion bits or bust".

jase.